The brain regions subserving the processing of emotional prosody have been investigated using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) but few studies investigated direct electrical neuronal activity using intracranial recordings in humans. Previous studies have shown the involvement of the amygdala and the orbito-frontal cortex (OFC) in the processing of emotional prosody. In this paper we present first evidence of functional neuronal coupling between these two regions in response to different kinds of emotional prosody.