This is a study of the interface between meaning and prosodic structure. Five syntactic types of questions were examined: positive yes/no, negative yes/no, positive declarative, negative declarative and wh-questions. 113 examples of English questions from the CallHome corpus were analyzed with respect to the effect nuclear tunes have on their meaning. We conclude that the direction of the final contour is the fundamental prosodic contributor to interactional pragmatic meaning.