In this paper, a new class of single-hidden layered linear-in-the-parameters, feedforward Artificial Neural Network (ANN) based adaptive non-linear filters is proposed for processing band-limited signals in a multi-microphone sub-band adaptive (MMSBA) speech enhancement system. Comparative results achieved in simulation experiments demonstrate that the proposed MMSBA system employing ANN based sub-band processing is capable of outperforming conventional noise cancellation schemes.