Mismatch negativity (MMN) was used to investigate the processing of cluster and noncluster initial consonants in consonant-vowel syllables in the human brain. The MMN was elicited by either syllable with cluster or noncluster initial consonant, phonetic contrasts being identical in both syllables. Compared to the noncluster consonant, the cluster consonant elicited a more prominent MMN. The MMN to the cluster consonant occurred later than that of the noncluster consonant. The topography of the mismatch responses showed clear left-hemispheric laterality in both syllables. However, the syllable with an initial noncluster consonant stimulus produced MMN maximum over the middle temporal gyrus, whereas maximum of the MMN activated by the syllable with initial cluster consonant was observed over the superior temporal gyrus. We suggest that the MMN component in consonant-vowel syllables is more sensitive to cluster compared to noncluster initial consonants. Spatial and temporal features of the cluster consonant indicate delayed activation of leftlateralized perisylvian cell assemblies that function as cortical memory traces of cluster initial consonant in consonant-vowel syllables. Keywords: EEG; Speech perception; Auditory cortex; MMN; Cluster consonants