Since auditory neural coding mechanisms have been uncovered using simple artificial stimuli, the nature of their involvement in speech perception has remained unclear. However, using analysis-resynthesis techniques, it is possible to design naturalistic speech stimuli that present the same appeal as artificial tones in terms of precise control and parametrisation. Here, speech stimuli were designed to assess the involvement of a specific coding mechanism: the coding of temporal fine structure through phase-locking. This mechanism is supposed to be impaired in cochlear synaptopathy, a form of hearing loss that remains undetected through pure tone audiometry. The design process described here seeks to accommodate all the constraints that can arise from large multi-centric studies covering different species, methodologies, and languages.