This paper presents an analysis of the influence of various system parameters on the output quality of our neural network based real-time EMG-to-Speech conversion system. This EMG-to-Speech system allows for the direct conversion of facial surface electromyographic signals into audible speech in real time, allowing for a closed-loop setup where users get direct audio feedback. Such a setup opens new avenues for research and applications through co-adaptation approaches. In this paper, we evaluate the influence of several parameters on the output quality, such as time context, EMG-Audio delay, network-, training data- and Mel spectrogram size. The resulting output quality is evaluated based on the objective output quality measure STOI.