Albayzin 2010 Text-to-Speech Evaluation Campaign was the second biannual Albayzin Campaign. A Spanish corpus was provided by the Group of Multimedia Technologies of the University of Vigo, and six teams developed a total of ten systems for the evaluation. A set of test sentences was released to be synthesized, and an on-line evaluation was conducted, focusing on naturalness, similarity to the original voice, and intelligibility. In this paper the evaluation details and results are described.