In this paper, a novel approach based on time-domain pitch-synchronous point-to-point (TD-PSPTP) model for speech synthesis is presented. Compared to TD-PSOLA, which is currently one of the most popular concatenation methods, TD-PSPTP model provides a wider range of pitch and time modification. The quality of synthesized speech by TD-PSPTP shows to be high, especially its capability of overcoming reverberation, existing in TD-PSOLA when there is a drastic prosodic modification. The computational expense of TD-PSPTP model is no higher than that of TD-PSOLA. It provides an efficient way for the real time implementation of synthesis system.